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Scott A. Barros, PhD, DABT Sr. Scientist, Toxicology What is an Aptamer? Aptamer Structure Medicinal Chemistry Process Increased plasma stability Increased affinity Increased potency Considerations in Safety Assessment of Aptamers In general, aptamers have toxicological properties similar to ...

http://www.massbio.org/writable/committees/presentations/mbc_21feb2008.ppt

Date added: October 30, 2011 - Views: 108

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... • Structural studies of aptamer-ligand complexes have provided a wealth of information regarding RNA structure and ligand interaction • Most aptamers exhibit conformational changes upon binding to ligand (induced fit binding) ...

http://chemistry.creighton.edu/~jksoukup/lecRiboswitches2008.ppt

Date added: October 31, 2011 - Views: 61

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Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins Stephanie J. Culler, Kevin G. Hoff, Christina D. Smolke

http://openwetware.org/images/4/44/Tinaandrew20.385.ppt

Date added: May 6, 2013 - Views: 10

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Impact Aptamer recognition elements enable detection of nucleic acids, proteins, small molecules, inorganic ions Accomplishments Smart electrode surfaces allow real-time detection of small molecule analytes Device integration: ...

http://www.strategicstudiesinstitute.army.mil/pdffiles/strat20/panel-1-kokoska/kokoska.ppt

Date added: October 12, 2011 - Views: 55

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The Detrimental Impact of Chronic Renal Insufficiency

Factor IXa Inhibition Aptamer Technology Overview and First Results with RB006/RB007 Mauricio G. Cohen, MD Associate Professor of Medicine Director, Cardiac Cath Lab

http://www.clinicaltrialresults.org/Slides/Factor%209%20inhibition%20via%20aptamer.ppt

Date added: November 8, 2011 - Views: 37

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Folie 1 - imb-jena.de

The Aptamer Database is a comprehensive, annotated repository for information about aptamers and in vitro selection. This resource is provided to collect, organize and distribute all the known information regarding aptamer selection.

http://www.imb-jena.de/www_bioc/3D/3D_LECTURE_2005_2.ppt

Date added: June 11, 2013 - Views: 5

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NCI Alliance for Nanotechnology in Cancer: Research Advances ...

... ErbB3 Targeted Aptamer-Nanoparticle Conjugate, Massachusetts General Hospital, Boston, Mass. Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina, Chapel Hill, N.C. Nanosystems Biology Cancer Center, ...

http://deainfo.nci.nih.gov/advisory/bsa/bsa0608/presentations/monday/1001%20Rosen.ppt

Date added: June 26, 2012 - Views: 38

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DNA-based cell targeting - OpenWetWare - Main Page - OpenWetWare

Design options A: Aptamer-based Good: It’s simple. It’s been done before with success. Bad: Requires design of different aptamer sequences that can bind to cell-surface protein. B: Biotin/Streptavidin Good: Depends on association b/w biotin and streptavidin.

http://openwetware.org/images/d/d2/Targeting.ppt

Date added: March 31, 2012 - Views: 10

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Introduction Basic processes Features 2. Methods 3. Aptamer base 1. SELEX (systematic evolution of ligands by exponential enrichment) is a process that ...

http://www.biopharmagen.com/SELEX%20by%20%20褚畅.ppt

Date added: November 24, 2013 - Views: 36

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He, et al., Chemical Science, 2011 Aptamer-Based SERS Assay L. He, et al., Chemical Science, 2011 Raman shift (cm-1) Assignments Aptamer (*) 1316 Adenine (ring stretching) 1022 DNA backbone(PO2- stretching) 792 thymine, cytosine 735 Adenine (ring breathing) ...

http://blog.lib.umn.edu/chaynes/8152/Lecture21_clh_class.ppt

Date added: November 25, 2011 - Views: 13

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Reserve your “block” now We have developed a proprietary, high-throughput process for DNA aptamer production. Supply any protein target, and receive a custom, high affinity DNA aptamer in just weeks.

http://www.iceninebio.com/aptamer/aptamer-services.ppt

Date added: February 17, 2014 - Views: 1

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Label-Free Protein Biosensor Based on Aptamer-Modified Carbon ...

Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors Kenzo Maehashi, Taiji Katsura, Kagan Kerman, Yuzuru Takamura,

http://light.eecs.berkeley.edu/courses/ee235_sp07/student_presentations/0305/(4)%2003052007_Ryan_EE235.ppt

Date added: November 30, 2012 - Views: 15

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WHAT FACTORS PROMOTE THE EMERGENCE OF BIOCOMPLEXITY? Robert M. Hazen, Carnegie Institution Kavli Futures Symposium – Bio & Nano June 13, 2007

http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/KavliComplexity-13JUN07.ppt

Date added: December 29, 2013 - Views: 2

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15 Slides.ppt - Test Page for Apache Installation

… an ‘expression platform’ for gene regulation. A metabolite-binding ‘aptamer’ domain and … Riboswitch Functions U U U U U X 3 4 2 1 Direct (protein-free) binding of metabolite to RNA Metabolite-dependent regulation of genes These two activities are accomplished by two functionally ...

http://ender.bu.edu/~tgardner/be209/lectures/15/15%20Slides.ppt

Date added: February 2, 2012 - Views: 20

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Soontornworajit, B., Zhou, J., Zhang, Z., Wang, Y. Aptamer-functionalized in situ injectable hydrogel for controlled protein release. Biomacromolecules. 2010; 11: 2724-2730.

http://www.nsf.gov/mps/dmr/highlights/11highlights/highlights2011/0955358_Wang.ppt

Date added: September 9, 2014 - Views: 1

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Overview of your immune system - Information Management ...

... 657 RNA aptamers -- antibody-like properties Vitamin b12-binding RNA aptamer Slide 10 Let the immune system make enzymes for you Wedemayer et al. (1997) Science 276, 1665-1669. Catalytic antibody that hydrolyzes cocaine Zhu et al., 2006, ...

http://www.its.caltech.edu/~bi1/archives/files_2011/lectures/lecture26/lecture26.ppt

Date added: January 29, 2013 - Views: 19

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One anti-Rev aptamer: binds peptide in alpha-helical conformation Another anti-Rev aptamer: binds peptide in an extended conformation MS2 protein as beta sheet bound via protruding side chains DNA synthesizer T7 prom PCR site random 1015 T7 polymerase, ...

http://www.cs.duke.edu/~reif/temp/aptamers/evolving%20aptamers/overview%20slides%20of%20SELEX/aptamers04.ppt

Date added: May 5, 2013 - Views: 38

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Aptamer antagonist of tissue factor pathway inhibitor. Improved thrombin generation in plasma from subjects with FVIII deficiency. Improved clot times as measured by thromboelastography in monkeys depleted of FVIII. Waters, Blood, 2009. Fucoidans.

http://www.ohsu.edu/xd/health/services/cancer/getting-treatment/why-ohsu/for-healthcare-professionals/continuing-ed/upload/Recht_12-01-21-bleeding-2012.pptx

Date added: April 19, 2013 - Views: 18

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Inquiry into Life Twelfth Edition - McGraw-Hill Education

... at the transcriptional level Others can function at the translational level Model of Riboswitch Action FMN binds to aptamer in a riboswitch called the RFN element in 5’-UTR of the ribD mRNA Binding FMN, ...

http://highered.mheducation.com/sites/dl/free/0072995246/444682/chapt07_lecture.ppt

Date added: August 9, 2014 - Views: 1

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S-aptamer-tagged ARE and mtARE reporters were used for in vivo Crosslinking-coupled RNP purificaiton followed by RPA assay High-mobility group A2 (HMGA2) 3’ UTR contains seven sites for the endogenous Let-7 High-mobility group A2 (HMGA2) ...

http://www.microbio.uab.edu/ptrm/2008/ChaoLi/li92308.ppt

Date added: June 1, 2013 - Views: 5

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... Another RNA aptamer example: adenosine aptamer Class II ligase ribozyme Pitt & Ferré-D’Amaré, J. Am. Chem. Soc., 2009, 131 (10), pp 3532–3540 Class II ligase ribozyme Rapid Construction of Empirical RNA Fitness Landscapes Jason N. Pitt and Adrian R. Ferré-D’Amaré* Science 2010: ...

http://www.chem.uci.edu/~aluptak/110715_UK_Lecture.ppt

Date added: December 10, 2013 - Views: 2

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REG1: Pegnivacogin + AnivamersenRegado Biosciences, Inc. Novel Anticoagulation System. RNA aptamer . Factor IXa inhibitor. Controlling agent. Active. Specific

http://clinicaltrialresults.org/Slides/RADAR%20ACC11%20LBCT%20040311%20final_Povsic.ppt

Date added: November 10, 2011 - Views: 11

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... First Anti Angiogenic Agent 28 Base RNA Aptamer NON-IMMUNOGENIC NATURE Selectively binds extra cellular VEGF 165 DOES NOT EFFECT NORMAL VASCUALR GROWTH BEVACIZUMAB (AVASTIN) Humanized mono-clonal antibody. Active Against all ...

http://www.jdosmp.org/pps/antiVEGF_rs.ppt

Date added: June 2, 2013 - Views: 31

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... Multiple Isoforms of VEGF-A Are Generated from Exon Splicing VEGF Inhibition in AMD FDA approved Pegaptanib Aptamer Specific for VEGF-A isoform 1651 Ranibizumab Recombinant, ...

http://www.projectsinknowledge.com/Init/MC/1772/1772-Slides.ppt

Date added: October 16, 2011 - Views: 81

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Class 27_11 last updated 12/14/11 12:30 PM Limitations of siRNA silencing in mammalian cells Transient nature of the response (~3 days) Transfection problems (cell type, refractoriness)

http://www.columbia.edu/cu/biology/courses/w3034/Larry/class27_11.ppt

Date added: January 27, 2012 - Views: 17

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Duke Clinical Research Institute - dukecardiologyfellows

VWF Aptamer and Murine Carotid Injury Nimjee S et al. Mol Therapy 2011 Universal Antidotes for VWF Aptamer CDP and VWF Aptamer PDA-DPA and VWF Aptamer Oney S et al. Nature Medicine Oct 4, 2009. Extracellular DNA Traps and Thrombosis Fuchs. PNAS 2010;107 ...

http://www.dukecardiologyfellows.org/dcfblog/wp-content/uploads/translational-science-20121.ppt

Date added: May 5, 2013 - Views: 13

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... Intracellular Lung Tarceva, Iressa Aptamer Cell Surface, Intracellular Renal, Lung AS1411 (in dev.) Peptide Cell Surface, Intracellular Breast, Thyroid RGD (in dev.) Targeting Agent Mode of Action Cancer Application Known Example(s) ...

http://unithertechnologyconference.com/downloads09/SessionsDayOne/BURGESS_web.ppt

Date added: November 11, 2011 - Views: 30

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... Intracellular Peptide AS1411 (in dev.) Cell Surface, Intracellular Aptamer Her2, Erbitux Cell Surface Monoclonal Antibody Functionality Dispersion - Effective aqueous dispersion must be demonstrated. Preliminary results are encouraging. (internal research) ...

http://unithertechnologyconference.com/downloads/SESSION%205/Burgess_NEW.ppt

Date added: November 5, 2011 - Views: 25

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... Selection against proteins - Selection of new ribozymes (RNA world) The ATP aptamer structure Nucleolin RNA Targets B1 10-50nM (5’ETS) Mouse B2 50-100nM (5’ETS) ...

http://www.mol.biol.ethz.ch/groups/allain_group/teaching/Ribozyme-course.ppt

Date added: October 7, 2011 - Views: 44

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aptamer. fragments. Anal Method . ... Lead: 100 ppt (2 orders of magnitude below the EPA standard limit) 2-3 orders of magnitude. Small molecules. 7 nM (5 orders of magnitude more sensitive than the colorimetric method) > 4 orders of magnitude. Explosive chemicals.

http://nanodiscoveryinc.com/yahoo_site_admin/assets/docs/NanoDLSay.50102502.pptx

Date added: June 10, 2013 - Views: 15

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CU Boulder Research, Scholarly Activity, and Creative Works GSAC April 30, 2010 Russ Moore, Interim VC Research Research & Scholarly Works Remarkable record of research and scholarly works achievement across all schools and colleges on our campus see http://www.colorado.edu/research/achievements ...

http://www.colorado.edu/graduateschool/aboutus/gsac/minutes/april10/GSAC(S10)RMpresentation.ppt

Date added: August 1, 2013 - Views: 269

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No Slide Title

Terminator Aptamer Research focus on riboswitches Bioinformatics Without TPP What are Riboswitches? Anti-terminator Aptamer Vitamin B1 biosynthesis in bacteria: TPP-mediated attentuation control: E. Nudler and coworkers: (Mironov et al., ...

http://in.bgu.ac.il/fohs/Documents/Presentations/dbarash_riboswitch_presentation_2013.ppt

Date added: July 30, 2013 - Views: 5

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No Slide Title

... 49-60 Aptamer remains receptive to FMN binding until it is disrupted by the formation of the antiterminator helix. = irreversible event of the riboswitch at low FMN concentrations longer transcripts have lower affinity aptamers of transcripts paused at PA and PB have affinities better ...

http://www.microbio.uab.edu/ptrm/neiderwies/niederweis.ppt

Date added: December 14, 2011 - Views: 25

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No Slide Title

Research focus on riboswitches Bioinformatics Searching for riboswitches in eukaryotes by their aptamer Sequence is not enough, need structure considerations! Research focus on riboswitches Bioinformatics Searching for riboswitches in eukaryotes by their aptamer (Cohen et al.,

http://in.bgu.ac.il/fohs/Documents/Presentations/dbarash_riboswitch_presentation_brief_2013.ppt

Date added: August 31, 2013 - Views: 1

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LEADERSHIP STEPS Understand the relevant research (UTeach/FRI), seek informed guidance (Master teachers—UTeach) Consult/involve faculty leaders (UTeach) or support a faculty initiative (FRI)

http://visionandchange.org/files/2013/09/Mary-Ann-Rankin.ppt

Date added: September 21, 2013 - Views: 2

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Anticoagulation: Past, Present and Future

... Factor IXa inhibitor (REG1) RB006, Injectable RNA aptamer that specifically binds and inhibits factor Ixa RB007, the complementary oligonucleotide that neutralizes its anti-IXa activity if & when needed Factor XI inhibitor Antisense oligonucleotide targeting factor XI ...

http://www.fpm.emory.edu/Family/didactics/powerpint/Anticoagulation_current_and_future_therapies.ppt

Date added: May 2, 2013 - Views: 20

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Indicator Displacement Assays for Solute Sensing

Indicator Displacement Assays for Solute Sensing Julee Byram Mecozzi Group May 10, 2007 * * * * * * * * * * * * * * * * * * * * * * * * * Aptamer-Based Sensor for Cocaine Stojanovic, M.N.; Prada, P.; Landry, D.W. J. Am. Chem. Soc. 2001, 123, 4928 518 nm 472 nm Kd ~ 100 μM Cocaine concentration ...

http://www.chem.wisc.edu/areas/organic/studsemin/byram/byram-sem.ppt

Date added: November 2, 2011 - Views: 17

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... Binds specific ligand Theophylline Theophylline aptamer Caffeine Synthesize de novo Terminator + YFP Add antiswitch On Off ‘Off’ antiswitch ‘On’ antiswitch Verify construction PCR products PCR products + Promoter ON OFF Caffeine Detector “Digital Decoder Device” Goal: ...

http://www.bio.davidson.edu/campbell/students/Gemberling_defense.ppt

Date added: September 17, 2013 - Views: 6

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Applications of Spectrophotometry - Schreiner University

An aptamer for a desired target molecule is chosen from a pool of random DNA or RNA sequences by successive cyclings of ... Arial Times New Roman Verdana Wingdings Globe Applications of Spectrophotometry Analysis of a Mixture Slide 3 Slide 4 Slide 5 Slide 6 Measuring an ...

http://faculty.schreiner.edu/bholloway/S%202006%20CHEM%203402%20Applications%20of%20Spectrophotometry-Sean%20Collins.ppt

Date added: April 23, 2012 - Views: 31

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Extensive and global regulation of transcription Shifts in

The portion that directly binds the ligand is the aptamer. Expression can be affected transcriptionally or post-transcriptionally. The ribD operon controls synthesis and transport of riboflavin and FMN.

http://www.sbs.utexas.edu/herrin/bio344/lectures/L11_proktransc4_Organ1.ppt

Date added: April 12, 2012 - Views: 18

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Diapositiva 1 - UB

Study of the interaction between the porphyrin TmPyP4 and the Thrombin Binding Aptamer (TBA) G-quadruplex Miquel del Toro1, Ramon Eritja2, Raimundo Gargallo1, ... guanine3 guanine4 pKa = 10,5 0,1 TmPyP4 Melting Acid base titration EXPERIMENTAL

http://www.ub.edu/gesq/dna/presentations/tba_tmpyp4.ppt

Date added: March 7, 2012 - Views: 16

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RNA secondary structure prediction and gene finding

The aptamer domain is a highly folded structure that selectively binds to the target metabolite. The expression platform converts metabolite binding events into changes in gene expression by harnessing changes in RNA folding that are brought about by ligand binding.

http://darwin.informatics.indiana.edu/col/courses/I519-12/Lecture/RNAfold.ppt

Date added: May 25, 2013 - Views: 30

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PEG PLGA Aptamer … + + + + Precipitate nanoparticles by dilution in water Mix in selected ratio Synthesis of 100 types of nanoparticles per minute Drug COOH NH PEG PLGA Aptamer … COOH NH PEG PLGA Aptamer … PEG PLGA Aptamer

http://www-mtl.mit.edu/mems/documents/Rohittalk.ppt

Date added: November 25, 2011 - Views: 41

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Riboswitches - Weizmann Institute of Science

... Aptamer domain (responsible for binding of ligand) Expression plataform (responsible for impacting gene expression) Structure Mechanism Three known mechanisms: Formation of intrinsic terminator stem (inhibits transcription by inducing its termination) ...

http://www.weizmann.ac.il/plants/aharoni/FrontiersCourse/Sharon-Riboswitches3.ppt

Date added: May 11, 2013 - Views: 20

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Prezentace aplikace PowerPoint

... 8% -> 96% REGULATION OF GENE EXPRESSION ANTISENSE STRATEGY interaction with RNA ANTIGENE STRATEGY interaction with DNA APTAMER STRATEGY interaction with proteins * ...

http://www.chtf.stuba.sk/~szolcsanyi/education/files/Organicka%20chemia%20II/Prednaska%2010_Nukleozidy/Doplnkove%20studijne%20materialy/BioorgNukleoSynt.ppt

Date added: December 21, 2013 - Views: 3

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RFID Biosensors for the Detection of IEDs at 400 m Stand-off ...

Presently involved in aptamer, peptide, antibody and plasma-deposited hydrogels research. Currently developing an RFID/Biosensor. Technology Background (3) RFID/Biosensor An interrogation unit transmits an RF signal to an RFID/Biosensor.

http://zensensing.com/media/powerpoint/Hunt-and-Edmonson-DARPA-Presentation-Nov-16-2005.ppt

Date added: May 2, 2013 - Views: 4

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Folie 1 - FLI - Leibniz

- 2013/2014 - 3D Structures of Biological Macromolecules Part 3: Nucleic Acids Jürgen Sühnel [email protected] Leibniz Institute for Age Research, Fritz Lipmann Institute,

http://www.fli-leibniz.de/www_bioc/3D/3D_LECTURE_2013_3.ppt

Date added: April 19, 2014 - Views: 6

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Synthetic Biology: Design and characterization of ...

Discuss different stems and discuss the single and anti-sense stem first, then mention aptamer stem -----> aptamers Antiswitch RNA molecules are too small to and require an exact sequence, they cannot be made directly in the cells.

http://www.bio.davidson.edu/campbell/students/NCAS_MPGmac.ppt

Date added: September 13, 2013 - Views: 3

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幻灯片 1 - Nature

Figure 1 Schematic representation of adherent cell-based aptamer selection Yan Tan1, # et al. Acta Pharmacol Sin 2013; 34: 1491–1498; doi: 10.1038/aps.2013.137

http://www.nature.com/aps/journal/v34/n12/slides/aps2013137-pf1.ppt

Date added: October 12, 2014 - Views: 1

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Slide 1

MG, the ligand for which the aptamer was originally selected, consistently has the more favorable enthalpy (heat) as well as a larger heat capacity (the dependence of enthalpy on temperature).

https://acswebcontent.acs.org/prfar/2008/NUGGET/9255/9255.PPT

Date added: September 21, 2014 - Views: 1