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Scott A. Barros, PhD, DABT Sr. Scientist, Toxicology What is an Aptamer? Aptamer Structure Medicinal Chemistry Process Increased plasma stability Increased affinity ...

http://www.massbio.org/writable/committees/presentations/mbc_21feb2008.ppt

Date added: October 30, 2011 - Views: 112

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Flavin mononucleotide RFN aptamer Genetic Control Mechanisms Tom Cech, Nature (2004) 428: 263-264. Genetic Control Mechanisms - RIBOSWITCHES Tom Cech, Nature ...

http://chemistry.creighton.edu/~jksoukup/lecRiboswitches2008.ppt

Date added: October 31, 2011 - Views: 62

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Label-Free Protein Biosensor Based on Aptamer-Modified Carbon ...

Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors Kenzo Maehashi, Taiji Katsura, Kagan Kerman, Yuzuru Takamura,

http://light.eecs.berkeley.edu/courses/ee235_sp07/student_presentations/0305/(4)%2003052007_Ryan_EE235.ppt

Date added: November 30, 2012 - Views: 15

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Impact Aptamer recognition elements enable detection of nucleic acids, proteins, small molecules, ... PowerPoint Presentation Last modified by: robert.kokoska

http://www.strategicstudiesinstitute.army.mil/pdffiles/strat20/panel-1-kokoska/kokoska.ppt

Date added: October 12, 2011 - Views: 55

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Overview of your immune system - Information Management ...

... 657 RNA aptamers -- antibody-like properties Vitamin b12-binding RNA aptamer Slide 10 Let the immune system make enzymes for you Wedemayer et al. ...

http://www.its.caltech.edu/~bi1/archives/files_2011/lectures/lecture26/lecture26.ppt

Date added: January 29, 2013 - Views: 21

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Tinaandrew20.385.ppt - OpenWetWare

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins Stephanie J. Culler, ... Specific Aptamer Input: Endogenous Protein ...

http://openwetware.org/images/4/44/Tinaandrew20.385.ppt

Date added: May 6, 2013 - Views: 10

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DNA-based cell targeting - OpenWetWare - Main Page - OpenWetWare

Bad: If we can control amount of aptamer bound to cell surface, probably can get as much/ better control by delivering protein bound directly to the aptamer.

http://openwetware.org/images/d/d2/Targeting.ppt

Date added: March 31, 2012 - Views: 10

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Supplementary Figure 1 A B 7.93 PEG-Aptamer 500 400 9.66 NH2-Aptamer 300 200 Absorbance (mAU) 100 7.93 PEG-Aptamer 300 250 200 150 100 50 5.0 10.0 15.0 20.0 25.0 ml

http://www.nature.com/mtna/journal/v3/n8/extref/mtna201441x3.ppt

Date added: November 21, 2014 - Views: 1

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Step 3) Replicate molecules (poorly) and repeat process several times to find an aptamer which binds better than all the rest to biotin (molecular evolution: ...

http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/KavliComplexity-13JUN07.ppt

Date added: December 29, 2013 - Views: 3

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Introduction Basic processes Features 2. Methods 3. Aptamer base 1. SELEX (systematic evolution of ligands by exponential enrichment) is a process that ...

http://www.biopharmagen.com/SELEX%20by%20%20%e8%a4%9a%e7%95%85.ppt

Date added: November 21, 2014 - Views: 1

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He, et al., Chemical Science, 2011 Raman shift (cm-1) Assignments Aptamer (*) 1316 Adenine (ring stretching) 1022 DNA backbone(PO2- stretching) 792 thymine, ...

http://blog.lib.umn.edu/chaynes/8152/Lecture21_clh_class.ppt

Date added: November 25, 2011 - Views: 13

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Factor IX a Inhibition Aptamer Technology Overview and First ...

Factor IXa Inhibition Aptamer Technology Overview and First Results with RB006/RB007 Mauricio G. Cohen, MD Associate Professor of Medicine Director, Cardiac Cath Lab

http://www.clinicaltrialresults.org/Slides/Factor%209%20inhibition%20via%20aptamer.ppt

Date added: November 8, 2011 - Views: 37

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Folie 1 - FLI - Leibniz Institute for Age Research

The Aptamer Database is a comprehensive, annotated repository for information about aptamers and in vitro selection. This resource is provided to collect, ...

http://www.imb-jena.de/www_bioc/3D/3D_LECTURE_2005_2.ppt

Date added: June 11, 2013 - Views: 5

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Slide 1

Reserve your “block” now We have developed a proprietary, high-throughput process for DNA aptamer production. Supply any protein target, and receive a custom ...

http://www.iceninebio.com/aptamer/aptamer-services.ppt

Date added: February 17, 2014 - Views: 1

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Slide 1

Aptamer vs, prostate cancer cell membrane antigen (PMSA), conjugated to rhodamine Potential use as an anticancer diagnostic, and therapeutic.

http://www.cs.duke.edu/~reif/temp/aptamers/evolving%20aptamers/overview%20slides%20of%20SELEX/aptamers04.ppt

Date added: May 5, 2013 - Views: 40

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DNA . ppt - Biology Resources

The DNA of the nucleus makes a single strand of messenger RNA (ribo-nucleic acid) which leaves the nucleus and builds up the protein in the cytoplasm.

http://www.biology-resources.com/powerpoints/Genetics/01-DNA/DNA.ppt

Date added: December 17, 2011 - Views: 260

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REG1: Pegnivacogin + AnivamersenRegado Biosciences, Inc. Novel Anticoagulation System. RNA aptamer . Factor IXa inhibitor. Controlling agent. Active. Specific

http://clinicaltrialresults.org/Slides/RADAR%20ACC11%20LBCT%20040311%20final_Povsic.ppt

Date added: November 10, 2011 - Views: 11

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Inquiry into Life Twelfth Edition - Innovative Learning ...

... in response to ligand binding are called riboswitches Riboswitch Action Region that binds to the ligand is an aptamer An expression platform is another module ...

http://highered.mheducation.com/sites/dl/free/0072995246/444682/chapt07_lecture.ppt

Date added: August 9, 2014 - Views: 1

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Aptamer antagonist of tissue factor pathway inhibitor. Improved thrombin generation in plasma from subjects with FVIII deficiency. ... PowerPoint Presentation

http://www.ohsu.edu/xd/health/services/cancer/getting-treatment/why-ohsu/for-healthcare-professionals/continuing-ed/upload/Recht_12-01-21-bleeding-2012.pptx

Date added: April 19, 2013 - Views: 19

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... Intracellular Lung Tarceva, Iressa Aptamer Cell Surface, Intracellular Renal, Lung AS1411 (in dev.) Peptide Cell Surface, Intracellular Breast, Thyroid RGD ...

http://unithertechnologyconference.com/downloads09/SessionsDayOne/BURGESS_web.ppt

Date added: November 11, 2011 - Views: 30

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Duke Clinical Research Institute - dukecardiologyfellows

Duke University School of Medicine Duke Cardiology GR, ... agent Oligonucleotide-based platelet antagonists Universal nucleic acid antidotes What is an Aptamer ?

http://www.dukecardiologyfellows.org/dcfblog/wp-content/uploads/translational-science-20121.ppt

Date added: May 5, 2013 - Views: 14

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Extensive and global regulation of transcription Shifts in

The aptamer is called the RFN ... 2 Slide 3 REGULON Extensive and global regulation of transcription in prokaryotes Slide 6 Endospore formation Slide 8 ...

http://www.sbs.utexas.edu/herrin/bio344/lectures/L11_proktransc4_Organ1.ppt

Date added: April 12, 2012 - Views: 20

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Bottom picture: four high school students and one REU student received the training of synthesizing aptamer-based nanostructured alginate hydrogels for drug release.

http://www.nsf.gov/mps/dmr/highlights/10highlights/highlights2010/0705716_Wang.ppt

Date added: November 21, 2014 - Views: 1

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... aptamer: target. Soontornworajit B, Zhou J, Shaw MT, Fan, TS, Wang Y. Chemical Communications 2010; 46:1857-1859. Nucleic Acid Aptamers . Single-stranded ...

http://omicsonline.org/editor-ppt/Yong_Wang.pptx

Date added: November 3, 2014 - Views: 1

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UK lecture - University of California, Irvine

... Another RNA aptamer example: adenosine aptamer Class II ligase ribozyme Pitt & Ferré-D’Amaré, J. Am. Chem. Soc., 2009, 131 (10), ...

http://www.chem.uci.edu/~aluptak/110715_UK_Lecture.ppt

Date added: December 10, 2013 - Views: 2

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S-aptamer-tagged ARE and mtARE reporters were used for in vivo Crosslinking-coupled RNP purificaiton followed by RPA assay High-mobility group A2 (HMGA2) ...

http://www.microbio.uab.edu/ptrm/2008/ChaoLi/li92308.ppt

Date added: June 1, 2013 - Views: 5

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No Slide Title

- Transcription termination (FMN riboswitch) ... Molecular Cell 18, 49-60 PB mimic aptamer 10 nM apparent KD: FMN binding FMN binding (165 ribD and 230 ribD) ...

http://www.microbio.uab.edu/ptrm/neiderwies/niederweis.ppt

Date added: December 14, 2011 - Views: 27

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Ribozyme course - ETH Zurich: Welcome to the Institute of ...

... Selection of new ribozymes (RNA world) The ATP aptamer structure Nucleolin RNA Targets B1 10-50nM (5’ETS) Mouse B2 50-100nM (5’ETS) ...

http://www.mol.biol.ethz.ch/groups/allain_group/teaching/Ribozyme-course.ppt

Date added: October 7, 2011 - Views: 49

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CNT/Conjugated-polymer Technological Advantages Mechanism of action well established Efficient conjugation of ... (in dev.) Cell Surface, Intracellular Aptamer ...

http://unithertechnologyconference.com/downloads/SESSION%205/Burgess_NEW.ppt

Date added: November 5, 2011 - Views: 25

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Inquiry into Life Twelfth Edition - 株式会社 化学同人

... Activation of mRNA Translation When TPP abundant Binds aptamer Causes conformational shift in mRNA Ties up Shine-Dalgarno in 2° structure Shift hides the SD ...

http://www.kagakudojin.co.jp/weaver/ppt_lecture/chapt17_lecture.ppt

Date added: February 5, 2012 - Views: 5

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Indicator Displacement Assays for Solute Sensing

Indicator Displacement Assays for Solute Sensing Julee Byram Mecozzi Group May 10, 2007 * * * * * * * * * * * * * * * * * * * * * * * * * Aptamer-Based Sensor for ...

http://www.chem.wisc.edu/areas/organic/studsemin/byram/byram-sem.ppt

Date added: November 2, 2011 - Views: 19

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Aptabody & Aptagenesis

T7 Synthesized N55 random oligo library N55 5’ Apta-switch Selection Strategy Promoter Random Region Primer Extension RT-PCR 5’ N55 Transcription Aptamer

http://www.aptagen.com/Content/Documents/downloadable-literature/Apta-switch%20SELEX%20Strategy.ppt

Date added: December 21, 2014 - Views: 1

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aptamer. fragments. Anal Method . 2011; 3:59-61. ... Lead: 100 ppt (2 orders of magnitude below the EPA standard limit) 2-3 orders of magnitude. Small molecules. 7 nM

http://nanodiscoveryinc.com/yahoo_site_admin/assets/docs/NanoDLSay.50102502.pptx

Date added: June 10, 2013 - Views: 16

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Slide 1

Re-iteration of the procedure will enrich for the aptamer until they dominate the population. At this point they can be cloned and sequenced.

http://www.columbia.edu/cu/biology/courses/w3034/2010/lacppts/class27_10.ppt

Date added: October 14, 2014 - Views: 1

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Applications of Spectrophotometry - Schreiner University ...

Applications of Spectrophotometry Ch. 19 Analysis of a Mixture The absorbance of a solution at any wavelength is the sum of the absorbances of all species in the ...

http://faculty.schreiner.edu/bholloway/S%202006%20CHEM%203402%20Applications%20of%20Spectrophotometry-Sean%20Collins.ppt

Date added: April 23, 2012 - Views: 37

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Slide 1

Class 27_11 last updated 12/14/11 12:30 PM Limitations of siRNA silencing in mammalian cells Transient nature of the response (~3 days) Transfection problems (cell ...

http://www.columbia.edu/cu/biology/courses/w3034/Larry/class27_11.ppt

Date added: January 27, 2012 - Views: 17

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Slide 1

... (Vienna RNA) Aptamer/Antiterminator/Terminator competition Evidence for natural selection of reliably folding sequences Probability of no selection P ~ 0.01 ...

http://www.math.rutgers.edu/events/smm/michael.widom.ppt

Date added: May 11, 2013 - Views: 10

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No Slide Title

Research focus on riboswitches Bioinformatics Searching for riboswitches in eukaryotes by their aptamer Sequence is not enough, need structure considerations!

http://in.bgu.ac.il/fohs/Documents/Presentations/dbarash_riboswitch_presentation_brief_2013.ppt

Date added: August 31, 2013 - Views: 1

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... Multiple Isoforms of VEGF-A Are Generated from Exon Splicing VEGF Inhibition in AMD FDA approved Pegaptanib Aptamer Specific for VEGF-A isoform 1651 ...

http://www.projectsinknowledge.com/Init/MC/1772/1772-Slides.ppt

Date added: October 16, 2011 - Views: 88

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The REU student is also working on the characterization of the aptamer-protein interactions with surface plasmon resonance.

http://www.nsf.gov/mps/dmr/highlights/09highlights/highlights2009/0705716_Wang.ppt

Date added: December 21, 2014 - Views: 1

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Increasing use of anit-VEGF in Ophthalmology

INCREASING USE OF Anti VEGF IN OCULAR ... First Anti Angiogenic Agent 28 Base RNA Aptamer NON-IMMUNOGENIC NATURE Selectively binds extra cellular ...

http://www.jdosmp.org/pps/antiVEGF_rs.ppt

Date added: June 2, 2013 - Views: 34

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NCI Alliance for Nanotechnology in Cancer: Research Advances ...

NCI Alliance for Nanotechnology in Cancer Value Proposition and Introductions Steven T. Rosen, M.D. Director, Robert H. Lurie Comprehensive Cancer Center

http://deainfo.nci.nih.gov/advisory/bsa/bsa0608/presentations/monday/1001%20Rosen.ppt

Date added: June 26, 2012 - Views: 41

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RNA secondary structure prediction and gene finding

Title: RNA secondary structure prediction and gene finding Author: System Support Last modified by: Haixu Tang Created Date: 11/8/2010 4:25:49 AM Document ...

http://darwin.informatics.indiana.edu/col/courses/I519-12/Lecture/RNAfold.ppt

Date added: May 25, 2013 - Views: 30

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Label-Free Protein Biosensor Based on Aptamer-Modified Carbon ...

Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors Author: Ryan Yang Last modified by: Ryan Yang Created Date:

http://light.eecs.berkeley.edu/courses/ee235_sp07/student_presentations/0321/%286%29%2003212007_Ryan_EE235.ppt

Date added: May 11, 2013 - Views: 10

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No Slide Title

Terminator Aptamer Research focus on riboswitches Bioinformatics Without TPP What are Riboswitches? Anti-terminator Aptamer Vitamin B1 biosynthesis in bacteria: ...

http://in.bgu.ac.il/fohs/Documents/Presentations/dbarash_riboswitch_presentation_2013.ppt

Date added: July 30, 2013 - Views: 5

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PSMA aptamer–Smg1 siRNA rejection of PSMA-expressing, but not parental, CT26 tumour cells. F Pastor et al. Nature 465, 227-230 (2010) doi:10.1038/nature08999

http://www.nature.com/nature/journal/v465/n7295/slides/nature08999-pf3.ppt

Date added: November 21, 2014 - Views: 1

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CU Boulder Research, Scholarly Activity, and Creative Works GSAC April 30, 2010 Russ Moore, Interim VC Research Research & Scholarly Works Remarkable record of ...

http://www.colorado.edu/graduateschool/aboutus/gsac/minutes/april10/GSAC(S10)RMpresentation.ppt

Date added: August 1, 2013 - Views: 309

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Anticoagulation: Past, Present and Future

Title: Anticoagulation: Past, Present and Future Author: n693173 Last modified by: Cathy Cheng Created Date: 9/27/2012 1:52:43 PM Document presentation format

http://www.fpm.emory.edu/Family/didactics/powerpint/Anticoagulation_current_and_future_therapies.ppt

Date added: May 2, 2013 - Views: 24

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Diapositiva 1 - Universitat de Barcelona - Home

Study of the interaction between the porphyrin TmPyP4 and the Thrombin Binding Aptamer (TBA) G-quadruplex Miquel del Toro1, Ramon Eritja2, Raimundo Gargallo1, Joaquim ...

http://www.ub.edu/gesq/dna/presentations/tba_tmpyp4.ppt

Date added: March 7, 2012 - Views: 19