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What is an Aptamer? ... used single-dose toxicology to support single dose in man Repeated-dose designs may mimic those for mAbs when PEGylated aptamer has long ...

http://www.massbio.org/writable/committees/presentations/mbc_21feb2008.ppt

Date added: October 30, 2011 - Views: 115

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Flavin mononucleotide RFN aptamer Genetic Control Mechanisms Tom Cech, Nature (2004) 428: 263-264. Genetic Control Mechanisms - RIBOSWITCHES Tom Cech, Nature ...

http://chemistry.creighton.edu/~jksoukup/lecRiboswitches2008.ppt

Date added: October 31, 2011 - Views: 62

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Overview of your immune system - Information Management ...

... 657 RNA aptamers -- antibody-like properties Vitamin b12-binding RNA aptamer Slide 10 Let the immune system make enzymes for you Wedemayer et al. ...

http://www.its.caltech.edu/~bi1/archives/files_2011/lectures/lecture26/lecture26.ppt

Date added: January 29, 2013 - Views: 26

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Label-Free Protein Biosensor Based on Aptamer-Modified Carbon ...

Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors Kenzo Maehashi, Taiji Katsura, Kagan Kerman, Yuzuru Takamura,

http://light.eecs.berkeley.edu/courses/ee235_sp07/student_presentations/0305/(4)%2003052007_Ryan_EE235.ppt

Date added: November 30, 2012 - Views: 15

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Can’t predict effects of aptamer location Must determine “optimal input-module location within intronic sequence space” for each regulatory device But is it ...

http://openwetware.org/images/4/44/Tinaandrew20.385.ppt

Date added: May 6, 2013 - Views: 10

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Institute for Collaborative Biotechnologies Dr. Robert Kokoska ... Impact Aptamer recognition elements enable detection of nucleic acids, proteins, ...

http://www.strategicstudiesinstitute.army.mil/pdffiles/strat20/panel-1-kokoska/kokoska.ppt

Date added: October 12, 2011 - Views: 55

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Folie 1 - FLI - Leibniz Institute for Age Research

The Aptamer Database is a ... Arial Trebuchet MS Times New Roman Humanst521 BT Modern Arial Unicode MS Standarddesign Folie 1 Folie 2 Folie 3 Folie 4 Folie 5 Folie ...

http://www.imb-jena.de/www_bioc/3D/3D_LECTURE_2005_2.ppt

Date added: June 11, 2013 - Views: 5

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He, et al., Chemical Science, 2011 Raman shift (cm-1) Assignments Aptamer (*) 1316 Adenine (ring stretching) 1022 DNA backbone(PO2- stretching) 792 thymine, ...

http://blog.lib.umn.edu/chaynes/8152/Lecture21_clh_class.ppt

Date added: November 25, 2011 - Views: 13

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Supplementary Figure 1 A B 7.93 PEG-Aptamer 500 400 9.66 NH2-Aptamer 300 200 Absorbance (mAU) 100 7.93 PEG-Aptamer 300 250 200 150 100 50 5.0 10.0 15.0 20.0 25.0 ml

http://www.nature.com/mtna/journal/v3/n8/extref/mtna201441x1.ppt

Date added: January 25, 2015 - Views: 1

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The Detrimental Impact of Chronic Renal Insufficiency

Aptamer Technology Overview and First Results with RB006/RB007 Mauricio G. Cohen, MD ... The Detrimental Impact of Chronic Renal Insufficiency Author: jzuccardy

http://www.clinicaltrialresults.org/Slides/Factor%209%20inhibition%20via%20aptamer.ppt

Date added: November 8, 2011 - Views: 38

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DNA-based cell targeting - OpenWetWare - Main Page - OpenWetWare

(DNA-based) cell targeting Overview Goals 3 designs Possible Implementation Future directions Goal (what we want) Control of substrate delivery to a cell.

http://openwetware.org/images/d/d2/Targeting.ppt

Date added: March 31, 2012 - Views: 10

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Slide 1

Reserve your “block” now We have developed a proprietary, high-throughput process for DNA aptamer production. Supply any protein target, and receive a custom ...

http://www.aptamers.com/wp-content/uploads/2009/09/Custom-DNA-aptamer-services_www-iceninebio-dotcom_ppt2003.ppt

Date added: May 11, 2013 - Views: 2

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Introduction Basic processes Features 2. Methods 3. Aptamer base 1. SELEX (systematic evolution of ligands by exponential enrichment) is a process that ...

http://www.biopharmagen.com/SELEX%20by%20%20%e8%a4%9a%e7%95%85.ppt

Date added: November 21, 2014 - Views: 1

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Step 3) Replicate molecules (poorly) and repeat process several times to find an aptamer which binds better than all the rest to biotin (molecular evolution: ...

http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/KavliComplexity-13JUN07.ppt

Date added: December 29, 2013 - Views: 3

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Inquiry into Life Twelfth Edition - Innovative Learning ...

Title: Inquiry into Life Twelfth Edition Author: Administrator Last modified by: Gail Hodge Created Date: 8/8/2006 9:50:44 PM Document presentation format

http://highered.mheducation.com/sites/dl/free/0072995246/444682/chapt07_lecture.ppt

Date added: August 9, 2014 - Views: 1

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DNA . ppt - Biology Resources

PowerPoint Presentation Author: Mackean Last modified by: Mackean Created Date: 10/22/2004 3:08:30 PM Document presentation format: On-screen Show Other titles:

http://www.biology-resources.com/powerpoints/Genetics/01-DNA/DNA.ppt

Date added: December 17, 2011 - Views: 269

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NCI Alliance for Nanotechnology in Cancer: Research Advances ...

NCI Alliance for Nanotechnology in Cancer Value Proposition and Introductions Steven T. Rosen, M.D. Director, Robert H. Lurie Comprehensive Cancer Center

http://deainfo.nci.nih.gov/advisory/bsa/bsa0608/presentations/monday/1001%20Rosen.ppt

Date added: June 26, 2012 - Views: 42

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RNA aptamer . Factor IXa inhibitor. Controlling agent. Active. Specific . Immediate. Titratable. Prior studies. Phase 1a, 1b, 1c (n = 174) Phase 2a PCI (n = 26)

http://clinicaltrialresults.org/Slides/RADAR%20ACC11%20LBCT%20040311%20final_Povsic.ppt

Date added: November 10, 2011 - Views: 11

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Aptamers as potential therapeutic molecules

Characterization of antithrombin-specific RNA aptamers for use in anticoagulant therapy Yolanda M. Fortenberry, Ph.D. Hematology 2014 Conference

http://omicsgroup.com/conferences/ACS/conference/speaker_ppt/14612-Speaker-ppt.ppt

Date added: November 21, 2014 - Views: 1

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Aptamer antagonist of tissue factor pathway inhibitor. Improved thrombin generation in plasma from subjects with FVIII deficiency. ... PowerPoint Presentation

http://www.ohsu.edu/xd/health/services/cancer/getting-treatment/why-ohsu/for-healthcare-professionals/continuing-ed/upload/Recht_12-01-21-bleeding-2012.pptx

Date added: April 19, 2013 - Views: 19

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Duke Clinical Research Institute - dukecardiologyfellows

Monoclonal Antibody Aptamer Aptamer Aptamer Antidote Aptamer Aptamer-antidote Pairs Aptamers Encode their Own Antidotes DCRI/ Regado Biosciences Anti -FIXa Aptamer ...

http://www.dukecardiologyfellows.org/dcfblog/wp-content/uploads/translational-science-20121.ppt

Date added: May 5, 2013 - Views: 15

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Bottom picture: four high school students and one REU student received the training of synthesizing aptamer-based nanostructured alginate hydrogels for drug release.

http://www.nsf.gov/mps/dmr/highlights/10highlights/highlights2010/0705716_Wang.ppt

Date added: November 21, 2014 - Views: 1

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Extensive and global regulation of transcription Shifts in

The portion that directly binds the ligand is the aptamer. Expression can be affected transcriptionally or post-transcriptionally.

http://www.sbs.utexas.edu/herrin/bio344/lectures/L11_proktransc4_Organ1.ppt

Date added: April 12, 2012 - Views: 23

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Slide 1

SELEX Have a random 40-mer synthesized, between 2 arbitrary 20-mers (PCR sites) 440 = 1024 Practical limit = 1015 = ~ 2 nmoles = ~ 50 ug DNA 1015 is a large number.

http://www.cs.duke.edu/~reif/temp/aptamers/evolving%20aptamers/overview%20slides%20of%20SELEX/aptamers04.ppt

Date added: May 5, 2013 - Views: 40

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Aptamer Based E-coli Detection in Waste Waters by Portable ...

Motivation. E. coli is appropriate indicator for monitoring potential enteric pathogens in waters. A microbiological indicator for fecal contamination in water and foods.

http://omicsgroup.com/conferences/ACS/conference/speaker_ppt/15632-Speaker-ppt.pptx

Date added: January 9, 2015 - Views: 1

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Slide 1

Class 27_11 last updated 12/14/11 12:30 PM Limitations of siRNA silencing in mammalian cells Transient nature of the response (~3 days) Transfection problems (cell ...

http://www.columbia.edu/cu/biology/courses/w3034/Larry/class27_11.ppt

Date added: January 27, 2012 - Views: 17

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... aptamer: target. Soontornworajit B, Zhou J, Shaw MT, Fan, TS, Wang Y. Chemical Communications 2010; 46:1857-1859. Nucleic Acid Aptamers . Single-stranded ...

http://omicsonline.org/editor-ppt/Yong_Wang.pptx

Date added: November 3, 2014 - Views: 1

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... Intracellular Lung Tarceva, Iressa Aptamer Cell Surface, Intracellular Renal, Lung AS1411 (in dev.) Peptide Cell Surface, Intracellular Breast, Thyroid RGD ...

http://unithertechnologyconference.com/downloads09/SessionsDayOne/BURGESS_web.ppt

Date added: November 11, 2011 - Views: 30

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... First Anti Angiogenic Agent 28 Base RNA Aptamer NON-IMMUNOGENIC NATURE Selectively binds extra cellular VEGF 165 DOES NOT EFFECT NORMAL VASCUALR GROWTH ...

http://www.jdosmp.org/pps/antiVEGF_rs.ppt

Date added: June 2, 2013 - Views: 34

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S-aptamer-tagged ARE and mtARE reporters were used for in vivo Crosslinking-coupled RNP purificaiton followed by RPA assay High-mobility group A2 (HMGA2) ...

http://www.microbio.uab.edu/ptrm/2008/ChaoLi/li92308.ppt

Date added: June 1, 2013 - Views: 6

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Label-Free Protein Biosensor Based on Aptamer-Modified Carbon ...

Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors Author: Ryan Yang Last modified by: Ryan Yang Created Date:

http://light.eecs.berkeley.edu/courses/ee235_sp07/student_presentations/0321/%286%29%2003212007_Ryan_EE235.ppt

Date added: May 11, 2013 - Views: 10

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Indicator Displacement Assays for Solute Sensing

Indicator Displacement Assays for Solute Sensing Julee Byram Mecozzi Group May 10, 2007 * * * * * * * * * * * * * * * * * * * * * * * * * Aptamer-Based Sensor for ...

http://www.chem.wisc.edu/areas/organic/studsemin/byram/byram-sem.ppt

Date added: November 2, 2011 - Views: 19

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Slide 1

Re-iteration of the procedure will enrich for the aptamer until they dominate the population. At this point they can be cloned and sequenced.

http://www.columbia.edu/cu/biology/courses/w3034/2010/lacppts/class27_10.ppt

Date added: October 14, 2014 - Views: 1

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Slide 1

... (Vienna RNA) Aptamer/Antiterminator/Terminator competition Evidence for natural selection of reliably folding sequences Probability of no selection P ~ 0.01 ...

http://www.math.rutgers.edu/events/smm/michael.widom.ppt

Date added: May 11, 2013 - Views: 10

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aptamer. fragments. Anal Method . 2011; 3:59-61. ... Lead: 100 ppt (2 orders of magnitude below the EPA standard limit) 2-3 orders of magnitude. Small molecules. 7 nM

http://nanodiscoveryinc.com/yahoo_site_admin/assets/docs/NanoDLSay.50102502.pptx

Date added: June 10, 2013 - Views: 18

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... Intracellular Peptide AS1411 (in dev.) Cell Surface, Intracellular Aptamer Her2, Erbitux Cell Surface Monoclonal Antibody Functionality Dispersion ...

http://unithertechnologyconference.com/downloads/SESSION%205/Burgess_NEW.ppt

Date added: November 5, 2011 - Views: 25

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High Efficiency Capture and Enumeration of Low Abundant ...

Target CTCs interact with antibody (EpCAM) coated microposts ... aptamer and. EpCAM antibody . HTMSU counted using fluorescence. microscopy . Dharmasiri, U.R.

http://mccarley.chemistry.lsu.edu/Chemistry%207800/Research%20Seminar-Udara.pptx

Date added: April 22, 2014 - Views: 11

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... Another RNA aptamer example: adenosine aptamer Class II ligase ribozyme Pitt & Ferré-D’Amaré, J. Am. Chem. Soc., 2009, 131 (10), ...

http://chem.ps.uci.edu/~aluptak/110715_UK_Lecture.ppt

Date added: May 3, 2013 - Views: 12

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Ribozyme course - ETH Zurich: Welcome to the Institute of ...

... Selection of new ribozymes (RNA world) The ATP aptamer structure Nucleolin RNA Targets B1 10-50nM (5’ETS) Mouse B2 50-100nM (5’ETS) ...

http://www.mol.biol.ethz.ch/groups/allain_group/teaching/Ribozyme-course.ppt

Date added: October 7, 2011 - Views: 50

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No Slide Title

... 313, 1752-6 regulatory elements which control a wide set of metabolic pathways in bacteria consist solely of RNA Aptamer domain: ...

http://www.microbio.uab.edu/ptrm/neiderwies/niederweis.ppt

Date added: December 14, 2011 - Views: 27

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Diapositiva 1 - Universitat de Barcelona - Home

Study of the interaction between the porphyrin TmPyP4 and the Thrombin Binding Aptamer (TBA) G-quadruplex ... guanine3 guanine4 pKa = 10,5 0,1 TmPyP4 Melting

http://www.ub.edu/gesq/dna/presentations/tba_tmpyp4.ppt

Date added: March 7, 2012 - Views: 19

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Title: PowerPoint Presentation Author: Mary Ann Rankin Last modified by: Yolanda George Created Date: 2/10/2013 6:32:04 PM Document presentation format

http://visionandchange.org/files/2013/09/Mary-Ann-Rankin.ppt

Date added: September 21, 2013 - Views: 3

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The REU student is also working on the characterization of the aptamer-protein interactions with surface plasmon resonance.

http://www.nsf.gov/mps/dmr/highlights/09highlights/highlights2009/0705716_Wang.ppt

Date added: December 21, 2014 - Views: 1

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No Slide Title

... RNA aptamer targets VEGF165 to treat neovascular age-related macular degeneration (US FDA approved) Inhibit HIV-1 References Calin, G. A. and Croce, ...

http://www.asip.org/about/documents/Sobel-SmallNucleicAcidMolecules.ppt

Date added: May 5, 2013 - Views: 9

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No Slide Title

Research focus on riboswitches Bioinformatics Searching for riboswitches in eukaryotes by their aptamer Sequence is not enough, need structure considerations!

http://in.bgu.ac.il/fohs/Documents/Presentations/dbarash_riboswitch_presentation_brief_2013.ppt

Date added: August 31, 2013 - Views: 1

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DNA Computing

Introduction Monochromophoric approach Bischromophoric Approach Conceptual framework Variations of structure-switching aptamer design schemes Real-time signaling ...

http://www.cs.duke.edu/~reif/temp/aptamers/flourescence%20signaling%20via%20aptamers/2004-05-18(sdkim).ppt

Date added: August 17, 2013 - Views: 3

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... Multiple Isoforms of VEGF-A Are Generated from Exon Splicing VEGF Inhibition in AMD FDA approved Pegaptanib Aptamer Specific for VEGF-A isoform 1651 ...

http://www.projectsinknowledge.com/Init/MC/1772/1772-Slides.ppt

Date added: October 16, 2011 - Views: 89

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Aptabody & Aptagenesis - Aptagen, LLC

Aptamer A=Aptamer T=target R=Ribozyme Negative/Counter Selection 5’ T7 Primer Extension 5’ RNA library Hammerhead ribozyme motif N55 N55 5’ Mg++ dependent ...

http://www.aptagen.com/Content/Documents/downloadable-literature/Apta-switch%20SELEX%20Strategy.ppt

Date added: December 21, 2014 - Views: 1

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PSMA aptamer–Smg1 siRNA rejection of PSMA-expressing, but not parental, CT26 tumour cells. F Pastor et al. Nature 465, 227-230 (2010) doi:10.1038/nature08999

http://www.nature.com/nature/journal/v465/n7295/slides/nature08999-pf3.ppt

Date added: November 21, 2014 - Views: 1